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Topical pain medications delivery allows a convenient, noninvasive, way to manage difficult types of pain. Side effects and drug interactions are minimized because, unlike oral or injected medications that require high blood levels to achieve effectiveness, topical creams are designed to provide high tissue concentrations without significant systemic absorption.
Topical delivery has another advantage in that the drug absorption rate through the skin is slower and tissue levels remain higher for longer periods. The skin acts as a drug reservoir. The subsequent slow release of drug from the subcutaneous tissue allows for a longer duration of action than is achieved with oral administration.